Draws against Sweden and Poland in their opening two games have left Spain right up against it, with goals a problem.
Cesar Azpilicueta has not played so far, but there is a clamour in Spanish media for him to return to provide leadership and allow Marcos Llorente, who has been playing at right-back, to resume his usual attacking role.
Captain and midfielder Sergio Busquets was sorely missed in Spain’s first two games due to testing positive for Covid-19, but is set to return here.
Here is how we predict the two teams will line up…
Slovakia vs Spain predicted lineups
Slovakia XI: Dubravka; Pekarik, Satka, Skriniar, Hubocan; Kucka, Hrosovsky; Haraslin, Hamsik, Mak; Duda
Spain XI: Simon; Azpilicueta, Laporte, Pau Torres, Gaya; Llorente, Busquets, Thiago; Gerard Moreno, Morata, Traore
Dubravka, Duda, Hubocan, Weiss (Slovakia) and Pau Torres, Rodri (Spain) will miss the next game if they are booked here.
Goalkeepers: Martin Dubravka, Marek Rodak, Dusan Kuciak
Defenders: Peter Pekarik, Lubomir Satka, Denis Vavro, Milan Skriniar, Tomas Hubocan, Jakub Holubek
Midfielders: Marek Hamsik, Stanislav Lobotka, Patrik Hrosovsky, Juraj Kucka, Ondrej Duda, Robert Mak, Vladimir Weiss, Laszlo Benes, Lukas Haraslin, Tomas Suslov, Matus Bero, Erik Jirka
Forwards: Michal Duris, Robert Bozenik, David Strelec
Goalkeepers: David de Gea, Robert Sanchez, Unai Simon
Defenders: Aymeric Laporte, Jose Gaya, Jordi Alba, Pau Torres, Eric Garcia, Diego Llorente, Cesar Azpilicueta
Midfielders: Marcos Llorente, Sergio Busquets, Rodri, Pedri, Thiago, Koke, Fabian
Forwards: Dani Olmo, Mikel Oyarzabal, Gerard Moreno, Alvaro Morata, Ferran Torres, Adama Traore, Pablo Sarabia