Health

Alcohol changes brain activity differently in male and female mice

Alcohol alters amgydala activity differently in male and female mice. Credit: DiLeo et al., eNeuro 2022

Alcohol alters synchronized brain activity in the amygdala of mice, but differently for male and female mice, according to new research published in eNeuro.

Alcohol misuse often goes hand-in-hand with anxiety and depression, and a brain region called the amygdala is involved in both. Changes in synchronized brain activity, called oscillations, between areas like the amygdala and prefrontal cortex can influence anxious and fearful behaviors in both rodents and humans. Yet how alcohol may impact the amygdala network to change behavior is not known.

DiLeo et al. administered alcohol to mice and measured corresponding changes in oscillatory states in the amygdala. Alcohol affected amygdala oscillations differently in male and female mice, especially after repeated alcohol administration. In fact, the oscillatory state of females did not change at all after repeated alcohol administration. The researchers repeated the experiment in mice without a subunit of a receptor linked to alcohol use and anxiety, which induced traits of the female network activity in males.

These results indicate alcohol can trigger the amygdala to switch activity states, which may drive changes in anxious and fearful behavior.


Scientists hunt for neurons responsible for alcohol withdrawal


More information:
Sex differences in the alcohol-mediated modulation of BLA network states, eNeuro (2022). DOI: 10.1523/ENEURO.0010-22.2022

Citation:
Alcohol changes brain activity differently in male and female mice (2022, July 4)
retrieved 4 July 2022
from https://medicalxpress.com/news/2022-07-alcohol-brain-differently-male-female.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Most Related Links :
todayuknews Governmental News Finance News

Source link

Back to top button